Browsing by Author "Palmer, Guy H."

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Expansion of variant diversity associated with high prevalence of pathogen strain superinfection under conditions of natural transmission

Uetia, Massaro W.; Tan, Yunbing; Broschat, Shira L.; Castaneda Ortiz, Elizabeth J.; Camacho-Nuez, Minerva; Mosqueda, Juan J.; Scoles, Glen A.; Grimes, Matthew; Brayton, Kelly A.; Palmer, Guy H. (Infection and Immunity, 2012-07)

Superinfection occurs when a second, genetically distinct pathogen strain infects a host that has already mounted an immune response to a primary strain. For antigenically variant pathogens, the primary strain itself ...
Primary structural variation in Anaplasma marginale Msp2 efficiently generates immune escape variants

Graca, Telmo; Paradiso, Lydia; Broschat, Shira L.; Noh, Susan M.; Palmer, Guy H. (Infection and Immunity, 2015-11)

Antigenic variation allows microbial pathogens to evade immune clearance and establish persistent infection. Anaplasma marginale utilizes gene conversion of a repertoire of silent msp2 alleles into a single active expression ...