Now showing items 1-9 of 9
EFFECT OF IRON-NITROGEN COORDINATION (TYPE II BINDING) ON DRUG METABOLISM BY CYTOCHROME P450: STUDIES TO UNDERSTAND THE KINETICS, METABOLIC STABILITY AND REGIOSELECTIVITY
Cytochrome P450 (CYP) enzymes metabolize more than 80% of clinically used drugs. Given a large role of CYP enzymes in drug metabolism, one of the goals in pharmaceutical industry is to understand metabolic rate and ...
MONOLIGNOL AND LIGNAN BIOSYNTHETIC STUDIES: FROM REACTION MECHANISMS TO NEXT GENERATION SEQUENCING
Three objectives were studied: determination of the biochemical mechanisms of an
SYNTHESIS, MOLECULAR BIOLOGY, AND BIOANALYTICAL STUDIES OF A FLUORESCENT SEROTONIN LIGAND WITH 5-HT3A IN BULK AND SUPPORTED LIPID BILAYERS
The first part of this dissertation is based on the synthesis, characterization and binding of a fluorescent ligand (5-HT*) that binds to a recombinant Serotonin type 3 Receptor (5-HT3A). Here a linker and a fluorescent ...
New chemistry of S-nitrosothiols
Protein S-nitrosation is an important post-translational modification that not only transmits nitric oxide (NO) biological activity, but also regulates protein functions. However, development of reliable methods for the ...
LIGNIN UNLOCKING PROCESS IN WOOD-FEEDING TERMITES FOR EFFECTIVE BIOMASS SUGAR RELEASE
This study explored a unique lignin unlocking process in wood-feeding termite (WFT) Coptotermes formosanus (Shiraki) for subsequent effective polysaccharide utilization during the digestion of woody biomass. Utilization ...
Understanding the Physiological Significance of Ureide Transport Processes in Soybean (
The ureides allantoin and allantoic acid are the major long-distance forms of nitrogen (N) in nodulated tropical legumes like French bean (
CHARACTERIZATION OF MITOCHONDRIAL AND CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASES
As a folate-dependent enzyme, serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of L-serine and (6S)-H4PteGlun (tetrahydrofolate, THF) to glycine and (6S)-5,10-CH2-H4PteGlun. The glycine-forming ...
Fundamental Mechanism and Impact of Post Translational Modifications on Calsequestrin: Implications for Function
Calsequestrin, the major resident protein found within the sarcoplasmic reticulum (SR), is a critical component required for proper muscle function. Exicitation-contraction coupling in muscle is regulated through fine ...
Investigating the Electron Transfer Systems of the Endoplasmic Reticulum Membrane in Plants
Within the endoplasmic reticulum membrane there are two electron transfer systems (ETS): NADPH:cytochrome P450 reductase (ATR) transfers electrons to cytochrome P450 monooxygenases and NADH:cytochrome b5 reductase (CBR1) ...