Increasing numbers of licensed practical nurses (LPN) are seeking further education in order to advance to registered nurse (RN) status. This is in part due to changes in the healthcare industry and the demand for more RNs in the workforce. This has created a need for more effective LPN to RN transition courses available within nursing education programs. Attrition rates are variable among existing transition programs and more evidence based guidelines are needed in order to create successful programs. In this paper, Knowles' theory of adult learning is applied to a literature review resulting in proposed best practice guidelfes facilitating the academic and role transition of LPNs to RNs within Associate's Degree Nursing (ADN) programs.