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EFFECT OF IRON-NITROGEN COORDINATION (TYPE II BINDING) ON DRUG METABOLISM BY CYTOCHROME P450: STUDIES TO UNDERSTAND THE KINETICS, METABOLIC STABILITY AND REGIOSELECTIVITY
(2012)
Cytochrome P450 (CYP) enzymes metabolize more than 80% of clinically used drugs. Given a large role of CYP enzymes in drug metabolism, one of the goals in pharmaceutical industry is to understand metabolic rate and ...
SYNTHESIS AND CHARACTERIZATION OF NOVEL NITROGEN-CONTAINING LIGANDS FOR METAL ION SEPARATIONS
(2012)
A serious limiting factor in the continued development of nuclear power is the disposal of high-level radioactive waste from spent nuclear fuel. The PUREX process can be used for the recovery of U and Pu, but it does not ...
PROSTATE CANCER CELL CAPTURE USING IMMOBILIZED INHIBITORS OF PROSTATE-SPECIFIC MEMBRANE ANTIGEN
(2011)
Prostate cancer, especially its metastasis to the bone, is the leading cause of death for men in the US. The development of bone metastasis is a complex process that is potentially established by prostate circulating tumor ...
DETECTION OF THE ACTINIDES AND CESIUM FROM ENVIRONMENTAL SAMPLES
(2014)
Detection of the actinides and cesium in the environment is important for a variety of applications ranging from environmental remediation to safeguards and nuclear forensics. The utilization of multiple different elemental ...
Synthesis and Characterization of New Unsymmetrical Diglycolamides for Trivalent Lanthanide Metal Extraction
(2016)
Twelve new unsymmetrical diglycolamide (UDGA) ligands have been synthesized as solvent extraction reagents for trivalent lanthanide ions from highly acidic nitrate media. The asymmetry in the extractant design arises from ...
PROFILING DILUENT/EXTRACTANT/LANTHANIDE COMPLEX INTERACTIONS IN ADVANCED TALSPEAK SEPARATION SYSTEMS
(2017)
Solvent extraction has generally been the method of choice for the reprocessing of used nuclear fuel. Fundamentally, solvent extraction is based on the differences in solubility of chemical species dissolved in a biphasic ...
ELECTROCHEMICAL INVESTIGATIONS OF DOPAMINE USING ROTATING DISK ELECTRODE VOLTAMMETRY: STUDY OF RELEASE AND REUPTAKE KINETICS AND INHIBITION OF THE NEURONAL DOPAMINE TRANSPORTER
(2013)
The dopamine transporter (DAT) is the neuronal transporter for the neurotransmitter dopamine (DA). The use of rotating disk electrode voltammetry (RDEV) is a technique used to study transport of DA by DAT. This can be done ...
The Application of Electrospray Mass Spectrometry to Solution Speciation: An Integrated Experimental and Computational Approach
(2016)
Electrospray ionization mass spectrometry (ESI-MS) is a promising technique for the study of metal:ligand solution speciation. While ESI-MS is frequently used qualitatively with some success, quantitative use of the technique ...
TECHNETIUM (IV) COMPLEXATION CHEMISTRY WITH POLYAMINO POLYCARBOXYLATE LIGANDS
(2017)
99Technetium (t½ = 2.1×105 y) constitutes approximately 6.1% of the cumulative yield of thermal 235U thermal fission. In the +7 oxidation state, technetium has high aqueous solubility and forms the anionic structure TcO4- ...
Fundamental studies of actinyl cation-cation interactions in mixed-solvent media
(2016)
The actinide cations ranging from uranium to americium are unique from other metal cations in that they form nearly linear dioxo cations at or above the pentavalent oxidation state. While the overall formal charge of the ...