Now showing items 1-6 of 6
The Interaction Between Opioids and Cannabinoids in the Rat Periaqueductal Gray
Opioids and cannabinoids are well known for their analgesic properties. Both classes of drugs exert their effects, in part, by activating a descending pain modulatory pathway that includes the midbrain periaqueductal gray ...
MOLECULAR AND CELLULAR CONSEQUENCES OF DISEASE ASSOCIATED PROCESSING DEFECTS IN CONE PHOTORECEPTOR CYCLIC NUCLEOTIDE-GATED CHANNELS
Cyclic nucleotide-gated (CNG) channels are heterotetrameric (2A3:2B3) cation channels critical to the molecular cascade that couples light stimulus to membrane potential changes in photoreceptor cells. CNG channels are ...
Sleep Loss and Workload: Cognitive Effects and Physiology
This dissertation aims to investigate some of the complex interactions between sleep loss, workload, cognition, and physiology. In order to examine the effects of workload on fatigue (operationally defined as a state of ...
CONTRIBUTION OF TRPV1 VAGAL AFFERENT NEURONS IN THE DETECTION OF PATHOGENIC BACTERIAL COLONIZATION IN THE GUT: PUTATIVE ROLE(S) OF PRO-INFLAMMATORY CYTOKINES
Vagal efferent activation can reduce inflammation and disease activity in various animal models of intestinal inflammation, likely via a mechanism involving activation of a a7nAChR subtype. The current hypothesis for this ...
MOLECULAR MECHANISMS OF DRUG- AND NOISE-INDUCED HAIR CELL DEATH AND PROTECTION
Hearing loss is a common, debilitating disorder that often leads to social isolation and depression. The prevalence of hearing loss remains high (15%) due to a lack of adequate tools to prevent it. Hearing loss commonly ...