RSS 1.0Electronic dissertations and theses - Integrative Physiology and Neuroscience
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Impacts of disrupted stress responses on brain and behavior
(2019)Stress is a term used in everyday life to describe everything from feelings of anxiety and grief, to shock and fear. However, at their most basic level, these psychological expressions of stress are all driven by similar ... -
THE EFFECTS OF NICOTINICS ON THE DEVELOPING CEREBELLUM
(2019)Cerebellar injury or exposure to toxicants during development heightens the risk for neurodevelopmental disorders. Since the cholinergic system is critical in neuronal migration and circuit formation, the rapidly developing ... -
CANNABINOID TYPE 1 RECEPTOR EXPRESSION, SYNAPTIC FUNCTION, AND PERTURBATION WITHIN THE DEVELOPING CEREBELLAR CORTEX
(2019)The endocannabinoid receptor 1 (CB1R) plays a neuromodulatory role throughout the central nervous system. A large proportion of CB1Rs are concentrated within the cerebellar cortex, a brain region known to control motor ... -
EXCITATORY ACTIONS OF CANNABINOIDS ON VAGAL AFFERENT SIGNALING VIA TRP CHANNELS
(2019)Vagal afferent neurons transmit visceral information to the nucleus of the solitary tract (NTS) to regulate cardiovascular, respiratory, and gastrointestinal reflexes. Vagal afferent terminals release most glutamate via ... -
CB1 Receptor Involvement in Contextual Cocaine Memory Reconsolidation
(2019)Environmentally induced cocaine relapse is a major impediment in the treatment of substance use disorders. Re-exposure to a cocaine-associated context can trigger the retrieval of context-cocaine memories which renders ... -
MOLECULAR MECHANISMS OF DRUG- AND NOISE-INDUCED HAIR CELL DEATH AND PROTECTION
(2017)Hearing loss is a common, debilitating disorder that often leads to social isolation and depression. The prevalence of hearing loss remains high (15%) due to a lack of adequate tools to prevent it. Hearing loss commonly ... -
Sleep Loss and Workload: Cognitive Effects and Physiology
(2015)This dissertation aims to investigate some of the complex interactions between sleep loss, workload, cognition, and physiology. In order to examine the effects of workload on fatigue (operationally defined as a state of ... -
CONTRIBUTION OF TRPV1 VAGAL AFFERENT NEURONS IN THE DETECTION OF PATHOGENIC BACTERIAL COLONIZATION IN THE GUT: PUTATIVE ROLE(S) OF PRO-INFLAMMATORY CYTOKINES
(2012)Vagal efferent activation can reduce inflammation and disease activity in various animal models of intestinal inflammation, likely via a mechanism involving activation of a a7nAChR subtype. The current hypothesis for this ... -
The Interaction Between Opioids and Cannabinoids in the Rat Periaqueductal Gray
(2011)Opioids and cannabinoids are well known for their analgesic properties. Both classes of drugs exert their effects, in part, by activating a descending pain modulatory pathway that includes the midbrain periaqueductal gray ... -
MOLECULAR AND CELLULAR CONSEQUENCES OF DISEASE ASSOCIATED PROCESSING DEFECTS IN CONE PHOTORECEPTOR CYCLIC NUCLEOTIDE-GATED CHANNELS
(2011)Cyclic nucleotide-gated (CNG) channels are heterotetrameric (2A3:2B3) cation channels critical to the molecular cascade that couples light stimulus to membrane potential changes in photoreceptor cells. CNG channels are ... -
Neural Mechanisms for Control of Food Intake by Circulating and Central GLP-1
(2010)Glucagon-like peptide-1 (GLP-1), an endocrine satiation signal, is secreted by the intestinal `L' cells as well as a small population of neurons in the hindbrain. One of its diverse actions is reduction of food intake. ...