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Chronic alcohol consumption enhances myeloid-derived suppressor cells (MDSC) in B16BL6 melanoma-bearing mice
(Springer Science, 2010)
We previously found that chronic alcohol consumption decreases the survival of mice bearing subcutaneous B16BL6 melanoma. The underlying mechanism is still not completely understood. Antitumor T cell immune responses are ...
Pharmacokinetics, Pharmacodynamics, and Formulation Development of Hydrophobic Xenobiotics
Natural products are a reservoir of potential therapeutic agents. One such class of compounds are the polyphenols, small molecular weight compounds found in a range of plant sources that exhibit potent anti-cancer, ...
INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins. PARG participates ...
DEVELOPMENT OF THERAPEUTICS TARGETING THE HEPATOCYTE GROWTH FACTOR(HGF)/MET SYSTEM
In this dissertation I will describe the development of prototype small molecule therapeutics directed at the HGF/Met system. In addition I will introduce a new approach for quantitatively localizing Met at the sub-cellular ...
Characterization of the effects of free fatty acid receptor 4 (FFA4) agonists on human cancer cells
Dietary omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have many beneficial effects on human health. These include promising inhibitory effects on cancer cell growth and invasion. ...
Analytical Method Development, Pharmacokinetics, and Pharmacodynamics of Selected Polyphenols
Novel analytical methods were developed and validated according to the International Conference on Harmonization guidelines using high-performance liquid chromatography (HPLC) with ultraviolet (UV) and/or electrospray ...
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