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INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins. PARG participates ...
DEVELOPMENT OF THERAPEUTICS TARGETING THE HEPATOCYTE GROWTH FACTOR(HGF)/MET SYSTEM
In this dissertation I will describe the development of prototype small molecule therapeutics directed at the HGF/Met system. In addition I will introduce a new approach for quantitatively localizing Met at the sub-cellular ...