Now showing items 1-6 of 6
Characterization and pharmacogenetics of hepatic phase I exemestane metabolism
Exemestane (EXE) is an endocrine therapy used to combat postmenopausal breast cancer. Several studies have reported substantial differences in clinical outcomes between EXE-treated patients, as well as inexplicable ...
Characterization of the effects of free fatty acid receptor 4 (FFA4) agonists on human cancer cells
Dietary omega-3 fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have many beneficial effects on human health. These include promising inhibitory effects on cancer cell growth and invasion. ...
An Integrative Systems Approach to Predict Herb-Drug Interactions Quantitatively
Consumers often supplement their drug regimens with alternative therapies, including herbal products. Despite this widespread practice, reliable information to determine the risk or safety of herb-drug interactions is ...
INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER: DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins. PARG participates ...
Development of hysteresis analysis as a model-independent approach to assess temporal dissociation in pharmacokinetics and pharmacodynamics
Pharmacodynamic hysteresis is a loop, typically anti-clockwise, in the effect-concentration profile, resulting from temporal dissociation between elaboration of effect and changes in drug concentration. Hysteresis behavior ...
NOVEL THERAPEUTICS AND PATHOMECHANISMS IN HUMAN MENDELIAN DISORDERS: PHENYLKETONURIA, MAPLE SYRUP URINE DISEASE, AND SUCCINIC SEMIALDEHYDE DEHYDROGENASE DEFICIENCY
The body of this dissertation is focused on understanding the pathomechanisms and paving the way for new treatment paradigms in human metabolic disease, particularly phenylketonuria (PKU), maple syrup urine disease (MSUD), ...