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dc.creatorLockwood, Svetlana
dc.creatorBrayton, Kelly A.
dc.creatorBroschat, Shira L.
dc.description.abstractBackground: Multiple important human and livestock pathogens employ ticks as their primary host vectors. It is not currently known whether this means of infecting a host arose once or many times during evolution. Results: In order to address this question, we conducted a comparative genomics analysis on a set of bacterial pathogens from seven genera - Borrelia, Rickettsia, Anaplasma, Ehrlichia, Francisella, Coxiella, and Bartonella, including species from three different host vectors - ticks, lice, and fleas. The final set of 102 genomes used in the study encoded a total of 120,046 protein sequences. We found that no genes or metabolic pathways were present in all tick-borne bacteria. However, we found some genes and pathways were present in subsets of tick-transmitted organisms while absent from bacteria transmitted by lice or fleas. Conclusion: Our analysis suggests that the ability of pathogens to be transmitted by ticks arose multiple times over the course of evolution. To our knowledge, this is the most comprehensive study of tick transmissibility to date.en_US
dc.publisherBMC Genomics
dc.rightsCreative Commons Attribution 4.0 International
dc.titleComparative genomics reveals multiple pathways to mutualism for tick-borne pathogens
dc.description.versionPublished copy
dc.description.citationLockwood, S., K.A. Brayton, and S. L. Broschat. Comparative genomics reveals multiple pathways to mutualism for tick-borne pathogens. BMC Genomics, Vol.17, No. 481, Jul. 2016. doi:10.1186/s12864-016-2744-9. PMCID: PMC4930560.

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  • Broschat, Shira
    This collection features research and educational materials by Shira Broschat, Professor and Curriculum Coordinator for the School of Electrical Engineering and Computer Science at Washington State University.

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Creative Commons Attribution 4.0 International
Except where otherwise noted, this item's license is described as Creative Commons Attribution 4.0 International