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dc.creatorZhang, Hui H.
dc.creatorMeadows, Gary G.
dc.date.accessioned2010-02-23T22:21:47Z
dc.date.available2010-02-23T22:21:47Z
dc.date.issued2010
dc.identifier.issn0340-7004 (print version)
dc.identifier.issn1432-0851 (electronic version)
dc.identifier.otherDOI:10.1007/s00262-010-0837-x
dc.identifier.urihttp://hdl.handle.net/2376/2321
dc.descriptionThe final publication is available at www.springerlink.com http://www.springerlink.comen_US
dc.description.abstractWe previously found that chronic alcohol consumption decreases the survival of mice bearing subcutaneous B16BL6 melanoma. The underlying mechanism is still not completely understood. Antitumor T cell immune responses are important to inhibiting tumor progression and extending survival. Therefore, we examined the effects of chronic alcohol consumption on the functionality and regulation of these cells in C57BL/6 mice that chronically consumed 20% (w/v) alcohol and subsequently were inoculated subcutaneously with B16BL6 melanoma cells. Chronic alcohol consumption inhibited melanoma-induced memory T cell expansion and accelerated the decay of IFN-Γ producing T cells in the tumor bearing mice. Foxp3+CD4+CD25+ regulatory T cells were not affected; however, the percentage of myeloid-derived suppressor cells (MDSC) was significantly increased in the peripheral blood and spleen. T cell proliferation as determined by carboxyfluorescein succinimidyl ester (CFSE) labeling experiments in vitro was inhibited by alcohol consumption relative to control water drinking melanoma-bearing mice. Collectively, these data show that chronic alcohol consumption inhibits proliferation of memory T cells, accelerates the decay of IFN-Γ producing CD8+ T cells, and increases MDSC, all of which could be associated with melanoma progression and reduced survival.en_US
dc.description.sponsorshipNational Institute for Alcohol Abuse and Alcoholism, RO1AA07293 and KO5AA017149en_US
dc.languageEnglish
dc.publisherSpringer Scienceen_US
dc.rightsIn copyright
dc.rightsopenAccess
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.rights.urihttp://purl.org/eprint/accessRights/OpenAccess
dc.subjectAlcohol consumptionen_US
dc.subjectMDSCen_US
dc.subjectMelanomaen_US
dc.subjectMemory T cellsen_US
dc.subjectInterferon gammaen_US
dc.titleChronic alcohol consumption enhances myeloid-derived suppressor cells (MDSC) in B16BL6 melanoma-bearing mice
dc.typeText
dc.description.citationZhang H, Meadows GG (2010) Chronic alcohol consumption enhances myeloid-derived suppressor cells (MDSC) in B16BL6 melanoma-bearing mice. Cancer Immunol Immunother 59(8): 1151-9.


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  • Zhang, Hui H.
    This collection features research by Hui Zhang, associate research professor nit the Department of Pharmaceutical Sciences at Washington State University
  • Meadows, Gary G.
    This collection features research by Gary Meadows, professor emeritus for the Department of Pharmaceutical Sciences at Washington State University.

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