Evaluation of Treatment Modalities in Radiotherapy Induced Esophagitis
MetadataShow full item record
Patients who have a diagnosis of non-small cell lung cancer (NSCLC) that necessitates the use of ionizing radiation to the chest and mediastinum unavoidably receive treatment to normal esophageal tissues. Damage to otherwise healthy tissue results as the esophageal mucosa lay within treatment fields. Repeated treatments over the course of prescribed radiation treatments results in radiotherapy induced esophagitis. The purpose of this project is to contrast the efficacy of two currently used treatment modalities for the treatment of radiotherapy induced esophagitis. Each study subject will be assigned through a random drawing, either Group A, Reynold's Solution, or Group B, sucralfate and fluconazole. Using a repeated measures design, study patients will be asked to provide subjective information regarding the symptoms as they relate to swallowing difficulty (dysphagia) and pain with swallowing (odynophagia). Patients will be asked to provide six (6) recordings of swallowing experiences they have while receiving their prescribed radiotherapy and study medications.