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dc.contributor.advisorSimasko, Steven M.
dc.creatorRiley, Timothy Paul
dc.date.accessioned2012-10-11T21:47:18Z
dc.date.available2012-10-11T21:47:18Z
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/2376/4174
dc.descriptionThesis (Ph.D.), Department of Veterinary and Comparative Anatomy Pharmacology and Physiology, Washington State Universityen_US
dc.description.abstractVagal efferent activation can reduce inflammation and disease activity in various animal models of intestinal inflammation, likely via a mechanism involving activation of a a7nAChR subtype. The current hypothesis for this pathway (termed the cholinergic anti-inflammatory pathway) suggests vagal efferent inflammatory inhibition is dependent on vagal afferent stimulation. However, little is known about what leads to afferent activation and what fiber type is responsible for transmitting this information to the brain especially in the context of subclinical or clinical pathogenic bacteria. To address these questions, we first determined if selectively lesioning vagal afferents altered c-Fos expression in the nucleus of the solitary tract (nTS) or altered animal survival after mice were either inoculated withen_US
dc.description.sponsorshipDepartment of Veterinary and Comparative Anatomy, Pharmacology & Physiology, Washington State Universityen_US
dc.languageEnglish
dc.rightsIn copyright
dc.rightsLimited public access
dc.rightsrestrictedAccess
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/
dc.rights.urihttp://www.ndltd.org/standards/metadata
dc.rights.urihttp://purl.org/eprint/accessRights/RestrictedAccess
dc.subjectNeurosciences
dc.subjectMicrobiology
dc.subjectImmunology
dc.subjectanti-inflammatory reflex
dc.subjectcampylobacter
dc.subjectlipopolysaccharide
dc.subjectsalmonella
dc.subjecttumor necrosis factor
dc.subjectvagus
dc.titleCONTRIBUTION OF TRPV1 VAGAL AFFERENT NEURONS IN THE DETECTION OF PATHOGENIC BACTERIAL COLONIZATION IN THE GUT: PUTATIVE ROLE(S) OF PRO-INFLAMMATORY CYTOKINES
dc.typeElectronic Thesis or Dissertation


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