Now showing items 1-10 of 12
New Chemistry of Sulfur Containing Molecules: Part1: Brook Rearrangement Mediated Synthesis of Disubstituted Thiophenes, Part 2: Application of S-Nitrosation in Organic Synthesis
Sulfur atoms are contained in a variety of functional groups across many organic molecules. Most of these functional groups are very interesting synthetic targets because of their significance in many research fields ...
New chemistry of S-nitrosothiols
Protein S-nitrosation is an important post-translational modification that not only transmits nitric oxide (NO) biological activity, but also regulates protein functions. However, development of reliable methods for the ...
DEVELOPMENT OF PSMA-TARGETED SPECT IMAGING AGENTS FOR PROSTATE CANCER
The cell-surface enzyme prostate-specific membrane antigen (PSMA) is up-regulated and strongly expressed on prostate cancer cells associated with high grade primary, androgen independent and metastatic tumors. The ability ...
Design, Synthesis and Evaluation of Glutamyl Sulfamides as Potential PSMA Inhibitors
Glutamate carboxypeptidase II (GCPII) is a membrane-bound cell-surface peptidase. When expressed on the epithelial of prostate cells it is know as prostate-specific membrane antigen (PSMA) and as N-acetyl-aspartyl-glutamate ...
The Evolution of Phosphoramidates from Small-Molecule Inhibitors to Tunable Cleavable Linkers
During the development of a series of phosphoramidate-based inhibitors to prostate-specific membrane antigen, we observed a trend in increasing acid stability as the distance between the phosphorus center and α-carboxylate ...
The Aziridine-Mediated Ligation and Efforts Towards a General Synthesis of N-terminal Aziridinyl Peptides
Herein is described the Aziridine-Mediated Ligation's discovery, conceptual development, and the efforts to develop a general synthetic method for the synthesis of unprotected peptide chains terminated in an aziridine. The ...
Application of the asymmetric [C+NC+CC] coupling reaction to synthesis
The asymmetric [C+NC+CC] coupling reaction provides stereoselective access to highly functionalized pyrrolidine rings. The hallmark of this azomethine ylide cycloaddition cascade is the ability to successfully employ ...
Development of Novel Controllable Hydrongen Sulfide Donors
Hydrogen sulfide (H
Inhibition and Absolute Quantitation of Human Aldehyde Oxidase
In recent years, aldehyde oxidase (AO) has continued to grow as an important enzyme in drug metabolism. Herein, we have focused primarily on the inhibition kinetics of AO and also developing tools to better understand AO ...
Synthetic uses of S-Nitrosothiols in Organic Chemistry
S-Nitrosothiols have risen to prominence since their identification as an important post-translational modification of cysteine residues. The full range of chemistry and biological implications of this motif are under ...