Now showing items 1-10 of 52
Understanding the Physiological Significance of Ureide Transport Processes in Soybean (
The ureides allantoin and allantoic acid are the major long-distance forms of nitrogen (N) in nodulated tropical legumes like French bean (
Identifying Regulatory Components of Phytosterol Biosynthesis in the Genomics Era
The biosynthesis of sterol molecules is both ubiquitous and essential in the eukaryotic lineage. Despite our advanced knowledge of the structural genes and enzymes involved in phytosterol biosynthesis in Arabidopsis thaliana, ...
Insights into the Maternal Age Effect on Aneuploidy
Humans face extraordinary difficulties in reproduction, as over 10% of all pregnancies are aneuploid. In most cases, aneuploidy causes complications in development; indeed, it is the leading known cause of miscarriage and ...
CHARACTERIZATION OF MITOCHONDRIAL AND CYTOSOLIC SERINE HYDROXYMETHYLTRANSFERASES
As a folate-dependent enzyme, serine hydroxymethyltransferase (SHMT) catalyzes the reversible conversion of L-serine and (6S)-H4PteGlun (tetrahydrofolate, THF) to glycine and (6S)-5,10-CH2-H4PteGlun. The glycine-forming ...
JASMONATE BIOSYNTHESIS AND SIGNALING IN THE BALANCE OF PLANT GROWTH AND DEFENSE
Jasmonic acid (JA) is a plant hormone that controls many aspects of growth, development, and defense. As a defense hormone JA is rapidly synthesized in response to wounding, or attack from herbivores and pathogens, triggering ...
Optimizing the Enzyme/Prodrug Axis of Suicide Gene Therapy Using Protein Engineering Strategies
The unifying goal of cancer therapy is to selectively eradicate cancer cells while sparing normal tissue from damage. As many current anticancer therapies lack specificity and cause unwanted side effects there is an unmet ...
Characterization of Cobalamin-Dependent Radical S-Adenosyl-L-Methionine Methyltransferases Involved in Antibiotic Biosynthesis
Due to increasing antibiotic resistance among dangerous pathogens, there is a critical need for new antibiotics. Enzymes represent a powerful tool for antibiotic production and discovery, however more enzymatic mechanisms ...
Isolation of ABA-response mutants in allohexaploid bread wheat (Triticum aestivum L.): Drawing connections to grain dormancy, preharvest sprouting, and drought tolerance
This dissertation describes the characterization of seed dormancy and drought tolerance phenotypes of abscisic acid (ABA) response mutants in allohexaploid wheat (
Nesprin-2G and cell-matrix adhesions influence cell migration during skin wound healing
Human skin is essential for separating internal organs from environmental, physical, and biological insults. The skin is composed of two layers, the epidermis and dermis, which are composed of primarily keratinocytes and ...
To Be, or Not to Be: The Molecular Mechanisms that Regulate Spermatogonial Stem Cell Fate
Spermatogonial stem cells (SSCs) are a rare population of cells in the male germ line that self-renew and differentiate into progenitor spermatogonia for the initiation of spermatogenesis. In mammalian males, this process ...